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About NAMZARIC ™ NAMZARIC is a once-daily, fixed-dose combination of memantine hydrochloride extended-release, a NMDA receptor antagonist, and donepezil hydrochloride, an acetylcholinesterase inhibitor.

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Recommendation 1 continues that the decision to initiate a trial of therapy should be based on an individualized assessment.

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One metabolite, 6-O-desmethyldonepezil, possesses a pharmacological activity similar to donepezil, but has a negligible pharmacodynamic (PD) effect due to its low concentration in plasma.

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From a practical standpoint, although other cholinesterase inhibitors have previously been demonstrated to reduce hypersensitivity after nerve injury in animals, this is the first study to examine a clinically available and well-tolerated cholinesterase inhibitor.

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