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About NAMZARIC ™ NAMZARIC is a once-daily, fixed-dose combination of memantine hydrochloride extended-release, a NMDA receptor antagonist, and donepezil hydrochloride, an acetylcholinesterase inhibitor.

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Antiemetics such as prochlorperazine or metoclopramide may be needed early on with the initiation of opioid therapy.

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The protocol for this study was designed in accordance with the ethical guidelines for epidemiology study established by Japan's Ministry of Education, Culture, Sports, Science and Technology in December 2008.

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Recommendation 1 continues that the decision to initiate a trial of therapy should be based on an individualized assessment.

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Both D1 and D2 receptor inhibition affected sign- and goal-tracking performance.

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One metabolite, 6-O-desmethyldonepezil, possesses a pharmacological activity similar to donepezil, but has a negligible pharmacodynamic (PD) effect due to its low concentration in plasma.

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Although in the first 12 months of treatment with donepezil there was a significant reduction in the number of cases converting to dementia, this was not sustained over 36 months.

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From a practical standpoint, although other cholinesterase inhibitors have previously been demonstrated to reduce hypersensitivity after nerve injury in animals, this is the first study to examine a clinically available and well-tolerated cholinesterase inhibitor.

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XR with other NMDA antagonists (amantadine, ketamine, or dextromethorphan) has not been systematically evaluated and such use should be approached with caution.

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The most common adverse events, defined as those occurring at a frequency of at least 5% in patients receiving donepezil hydrochloride and at twice or more the placebo rate, are largely predicted by donepezil hydrochloride cholinomimetic effects.

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David Hogan, in an accompanying editorial, correctly questions aspects of the clinical significance of donepezil because this and nearly all other cholinesterase inhibitor trials were not designed to measure the number of individual patients who actually gain worthwhile benefits.

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