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The pancreas at this juncture is in a deadlock; if it increases its insulin production in response to dietary stimulants in the absence of a calorie deficit, this may serve to exacerbate the IMCL content in it, which progressively make things worse.

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Purification and properties of the human placental insulin receptor.

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Mulligan, too, found that insulin sensitivity was reduced by 10% in people taking antiretroviral regimens that excluded PIs.

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